TauAD: MRI-free Tau Anomaly Detection in PET Imaging by means of Conditioned Diffusion Fashions
Authors: Lujia Zhong, Shuo Huang, Jiaxin Yue, Jianwei Zhang, Zhiwei Deng, Wenhao Chi, Yonggang Shi
Abstract: The emergence of tau PET imaging over the last decade has enabled Alzheimer’s sickness (AD) researchers to take a look at tau pathology in vivo and additional efficiently characterize the sickness trajectories of AD. Current tau PET analysis methods, nonetheless, normally perform inferences on huge cortical ROIs and are restricted inside the detection of localized tau pathology that varies all through subjects. Furthermore, a high-resolution MRI is required to carry out typical tau PET analysis, which is not typically acquired in scientific practices and might be not acquired for lots of aged victims with dementia on account of sturdy motion artifacts, claustrophobia, or positive metallic implants. On this work, we recommend a novel conditional diffusion model to hold out MRI-free anomaly detection from tau PET imaging data. By along with individualized circumstances and two complementary loss maps from pseudo-healthy and pseudo-unhealthy reconstructions, our model computes an anomaly map all through your full thoughts house that allows merely teaching a help vector machine (SVM) for classifying sickness severity. We observe our model on ADNI subjects (n=534) and contemplate its effectivity on a separate dataset from the preclinical subjects of the A4 scientific trial (n=447). We show that our approach outperforms baseline generative fashions and the usual Z-score-based approach in anomaly localization with out mis-detecting off-target bindings in sub-cortical and out-of-brain areas. By classifying the A4 subjects primarily based on their anomaly map using the SVM educated on ADNI data, we current that our approach can effectively group preclinical subjects with significantly completely completely different cognitive capabilities, which further demonstrates the effectiveness of our approach in capturing biologically associated anomaly in tau PET imaging.
