TauAD: MRI-free Tau Anomaly Detection in PET Imaging through Conditioned Diffusion Fashions
Authors: Lujia Zhong, Shuo Huang, Jiaxin Yue, Jianwei Zhang, Zhiwei Deng, Wenhao Chi, Yonggang Shi
Summary: The emergence of tau PET imaging during the last decade has enabled Alzheimer’s illness (AD) researchers to look at tau pathology in vivo and extra successfully characterize the illness trajectories of AD. Present tau PET evaluation strategies, nonetheless, usually carry out inferences on massive cortical ROIs and are restricted within the detection of localized tau pathology that varies throughout topics. Moreover, a high-resolution MRI is required to hold out typical tau PET evaluation, which isn’t generally acquired in scientific practices and is probably not acquired for a lot of aged sufferers with dementia as a result of robust movement artifacts, claustrophobia, or sure metallic implants. On this work, we suggest a novel conditional diffusion mannequin to carry out MRI-free anomaly detection from tau PET imaging information. By together with individualized circumstances and two complementary loss maps from pseudo-healthy and pseudo-unhealthy reconstructions, our mannequin computes an anomaly map throughout your complete mind space that permits merely coaching a assist vector machine (SVM) for classifying illness severity. We practice our mannequin on ADNI topics (n=534) and consider its efficiency on a separate dataset from the preclinical topics of the A4 scientific trial (n=447). We display that our technique outperforms baseline generative fashions and the standard Z-score-based technique in anomaly localization with out mis-detecting off-target bindings in sub-cortical and out-of-brain areas. By classifying the A4 topics based on their anomaly map utilizing the SVM educated on ADNI information, we present that our technique can efficiently group preclinical topics with considerably totally different cognitive capabilities, which additional demonstrates the effectiveness of our technique in capturing biologically related anomaly in tau PET imaging.
